Biological age of transplanted livers
نویسندگان
چکیده
منابع مشابه
Qualitative and Quantitative Analysis of the Effects of Quinazolinones on Internal Organs of Newborn Balb/C Mice
Objective(s) Quinazolinones are heterocyclic compounds, with biological and pharmacological activities, such as inhibiting some proteins, enzymes and reducing blood lipids. Materials and Methods Following previous results of our group, effects of two new derivatives of quinazolinones 9(3)-quinazolinone-2-propyl-2-phenylethyl (QPPE) and 9(3)-quinazolinone-2-ethyl-2-phenylethyl (QEPE) on liver...
متن کاملAccelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts.
BACKGROUND In living donor liver transplantation, the biological organ age of the donated allograft is unknown in young patients who receive grafts from older donors. Few studies have focused on the effects of aging on allografts in the state of tolerance. The purpose of this study was to assess the biological organ age of liver grafts. METHODS In 20 tolerated allografts over a 10-year post-t...
متن کاملGene Expression Profile in Liver Transplantation and the Influence of Gene Dysregulation Occurring in Deceased Donor Grafts
Background: Brain dead patients are the main source of organs for transplants. Brain death causes changes in peripheral organs. We define modifications of gene expression in specific pathways occurring in donor livers and their influence on gene expression profile of livers after transplant. Methods: We compared gene expression profile of both deceased donor livers and transplanted livers to ge...
متن کاملA Study of d-Amino Acid Oxidase, Uricase, and Choline Oxidase in the Livers and in Isolated Liver Cell Nuclei of Rats Bearing Transplanted Tumors*
Since the report of Brahn (1) that very low catalase values are found in the livers of human beings dead of various forms of cancer, many papers have appeared on the effect of a growing tumor upon enzyme systems in liver tissue. Greenstein (4) has shown that in rats bearing transplanted hepatoma 31 or Jensen sarcoma, or in mice bearing various transplanted tumors, the activity of the liver cata...
متن کاملA Metabolomic Approach (1H HRMAS NMR Spectroscopy) Supported by Histology to Study Early Post-transplantation Responses in Islet-transplanted Livers
Intrahepatic transplantation of islets requires a lot of islets because more than 50% of the graft is lost during the 24 hours following transplantation. We analyzed, in a rat model, early post-transplantation inflammation using systemic inflammatory markers, or directly in islet-transplanted livers by immunohistochemistry. 1H HRMAS NMR was employed to investigate metabolic responses associated...
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عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2018